Standing Embryos

Credit: Yoosik Kim & Stanislav Shvartsman, Princeton University Art of Science Competition

These vertical cross-sectional images of embryos of the common fruit fly (Drosophila melanogaster) are stained with antibodies in order to visualize molecules that subdivide the embryo into three tissue types: muscle, nervous system and skin. 

Obtaining such images is an engineering challenge since it requires upright positioning of a tiny embryo, which is shaped like an ellipsis and just a half-millimeter long. 

In collaboration with Lu lab at Georgia Tech, Princeton scientists have developed a device to trap and orient a large number of embryos vertically. The technique can be used to study embryos and, eventually, to understand the processes that drive the development of the embryo.

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livescience.com

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